Asian Journal
Of Traditional Medicines

Abstract: A series of phenolic acids from Pithecellobium clypearia have been isolated. Their stereochemical structures were determined by comprehensive spectroscopic data analyses. The tyrosinase inhibitory activity of all compounds was tested to investigate the effects on their melanogenesis. The result showed that compounds 1 and 5 exhibited higher tyrosinase inhibitory activities (inhibitory ratios at 92.15%, 93.57%, respectively) than the reference compound, arbutin (57.35%). Docking experiments were carried out in order to study the interactions between these compounds and mushroom tyrosinase.

Key words: Pithecellobium clypearia, tyrosinase inhibition, molecular docking