Asian Journal
Of Traditional Medicines

Abstract: Alzheimer’s disease (AD) is a genetically complex neurodegenerative disease and its pathological mechanism has not been fully discovered. In the current study, we have examined the medicinal effect of amide alkaloids of the Piper genus in the treatment of AD using network pharmacology. High-confidence level networks consisting of compound-protein target and protein targetpathway association were developed and the potential active amide alkaloids of the Piper genus, the potential target proteins and the key pathways were predicted by network pharmacology models. Overall, this approach provided a novel strategy to explore the role of amide alkaloids of the Piper genus in the treatment of AD from a holistic perspective.

Key words: Alzheimer’s disease, amide alkaloids, Piper genus, network pharmacology