The genus Crataegus: a review of phytochemistry
and pharmacology perspectives

The genus Crataegus: a review of phytochemistry and pharmacology perspectives

Jie Wang, Zhiyang Yan, Le Zhou, Xiaoxiao Huang*, Shaojiang Song*

Department of Natural Products Chemistry, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China

Received:2017-11-07 Revised:2018-07-09 Online:2018-10-20 Published:2018-11-13
Contact: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd., Shenyang 110016, China; Tel.: +86-24-23986510 (Xiaoxiao Huang); E-mail: xiaoxiao270@163.com (Xiaoxiao Huang); Tel.: +86-24-23986510 (Shaojiang Song); E-mail: songsj99@163.com (Shaojiang Song)

Abstract

Abstract: Plants of the genus Crataegus are widely distributed in North America and China. Edwards et al. reported the phytochemicals and pharmacology of Crataegus species in 2012. From 2012 to 2017, numerous articles have been published on the chemical constituents and pharmacologic effects of the genus Crataegus. To review chemical and pharmacologic advances and discuss the potential prospects for future investigation, the report summarized over 150 compounds isolated from Crataegus species, including flavonoids, triterpenoids, terpenes, lignans, hydroxycinnamic acids and phenols. These compounds exhibited wide range of bioactivities including antoxidant, anti-inflammatory, anti-tumor and anti-thrombotic activities.

Key words: Crataegus, chemical compositions, pharmacological effect, research review

Jie Wang, Zhiyang Yan, Le Zhou, Xiaoxiao Huang, Shaojiang Song. The genus Crataegus: a review of phytochemistry and pharmacology perspectives[J]. Asina Journal Of Traditional Medicines.

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