Network pharmacology-based screening of the active
ingredients and potential targets of the Patrinia villosa
for application to Alzheimer’s disease

Asian Journal of Traditional Medicines ›› 2020, Vol. 15 ›› Issue (1): 1-7.

Network pharmacology-based screening of the active ingredients and potential targets of the Patrinia villosa for application to Alzheimer’s disease

Shuhui Dong, Zhikang Duan, Ming Bai, Xiaoxiao Huang*, Shaojiang Song*

Department of Natural Products Chemistry, Key Laboratory of Computational ChemistryBased Natural Antitumor drug Research & Development, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China

Received:2018-12-26 Accepted:2019-04-18 Online:2020-02-20 Published:2020-03-31
Contact: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd., Shenyang 110016, China; Tel.: +86-24-23986510 (Xiaoxiao Huang); +86-24-23986510 (Shaojiang Song); E-mail: xiaoxiao270@163.com (Xiaoxiao Huang); songsj99@163.com (Shaojiang Song). E-mail:xiaoxiao270@163.com (Xiaoxiao Huang); songsj99@163.com (Shaojiang Song).

Abstract

Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder associated with global deterioration of intellectual function, including memory, learning, orientation, language, comprehension and judgment. Given the prevalence of AD and the lack of effective long-term therapies, there is a pressing need to discover viable leads that can be developed into clinically approved drugs with disease-modifying effects. The analysis of current reported literatures confirms the importance of Patrinia villosa J. as candidate against AD. Hence, the compound-disease target network based on the methods of network pharmacology prediction was established in this paper. The aim is to explore potential compounds with marked effect on AD in P. villosa. The result showed that the most effective compound in this plant might be threo-(7R,8R)-guaiacyl-glycerol-β-O-4′-dihydroconiferyl ether, and the most potential target might be Maltose-binding periplasmic.

Key words: Patrinia villosa J., network pharmacology, Alzheimer’s disease

Shuhui Dong, Zhikang Duan, Ming Bai, Xiaoxiao Huang, Shaojiang Song. Network pharmacology-based screening of the active ingredients and potential targets of the Patrinia villosa for application to Alzheimer’s disease[J]. Asian Journal of Traditional Medicines, 2020, 15(1): 1-7.

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