Asian Journal
Of Traditional Medicines

Abstract: Viburnum odoratissimum, a landscape plant, is rich in vibsane-type diterpenes, triterpenes, monoterpenoids, sesquiterpenoids, coumarins, and lignans and so on. In the present work, network analysis was carried out to predict the potential targets of V. odoratissimum and the treatment of related diseases. 13 main target proteins were predicted, as well as the diseases which might interact with the compounds from V. odoratissimum. The results showed that vibsane-type diterpenes and triterpenes had the potential to treat neoplasm-related and inflammation-related diseases, and the key target proteins were MDM2, NOS, AR, DNMT1, NR3C1, RARA and PTPN1. Among them, AR, NOS, DNMT1, NR3C1, DNMT1 and PTPN1 were also the crucial targets for triterpenes in the treatment of diabetes mellitus. Besides, ALOX15, PIPN1, TLR9, MIT, DNMT1, RAC1, RTGS2, RARA and ACHE were the potential targets for coumarins and lignan in the treatment of neoplasm-related diseases. Furthermore, ESR1, AR, NOS2, NR3C1 were the primary targets for monoterpenoids and sesquiterpenoids because of their potential neuroprotective effects. It is noteworthy that the study of the potential targets and related diseases can provide new insights for further development of V. odoratissimum.

Key words: Viburnum odoratissimum, target proteins, network, diseases