Asian Journal
Of Traditional Medicines

Abstract: An endophytic fungus Aspergillus fumigatus, isolated from the fruits of Solanum insanum L., was cultured in potato dextrose
broth medium. Chromatographic separation of the EtOAc extract led to the isolation of six secondary metabolites, identified
as pseurotin A (1), fumigaclavine C (2), monomethylsulochrin (3), trypacidin (4), fumiquinazoline C (5) and guignasulfide (6)
by spectral means. Compounds 2 and 3 showed brine shrimp toxicity with IC50 values of 147 and 74.2 μM, respectively, while
compounds 4 and 5 showed slight inhibition on the growth of fungal pathogen Cladosporium cladosporioides. This is the first
report of the isolation of guignasulfide (6) from A. fumigatus, which has been previously isolated only from an endophytic fungus
Guignardia sp.

Key words: Aspergillus fumigatus, Endophytic fungi, Solanum insanum, Guignasulfide