A network pharmacology-based study on the effect of Periploca forrestii Schltr. on hepatocellular carcinoma

Abstract

Abstract: Hepatocellular carcinoma (HCC) remains the sixth most common malignancy and the fourth leading cause of cancer death worldwide. Numerous Chinese herbs have been used to prevent and treat HCC. Periploca forrestii Schltr., belonging to the family of Asclepiadaceae, has been reported to have strong inhibitory efficacy against various types of cancer cells, but the mechanism is unclear. Hence, we utilized the compound-disease target network based on the network pharmacology analysis to find out the active ingredients from P. forrestii and the potential target proteins involved in hepatocellular carcinoma. The results showed that the most effective compounds in this plant might be caffeoylquinic acids and the most potential target might be GMP synthase [glutamine-hydrolyzing] (PDB: 2vxo). This study is of great significance to the further research of P. forrestii and provides a novel treatment strategy for HCC.

Key words: Periploca forrestii Schltr., hepatocellular carcinoma, network pharmacology

Shuang Qiu, Peng Zhao, Xiaoxiao Huang, Shaojiang Song. A network pharmacology-based study on the effect of Periploca forrestii Schltr. on hepatocellular carcinoma[J]. Asian Journal of Traditional Medicines, 2021, 16(3): 115-124.

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