Asian Journal
Of Traditional Medicines

Abstract: In order to study the possibility of hydroxytyrosol (HT) as a drug, we used SwissADME system to predict ADME of HT and pkCSM system to predict Tox of HT. The results show that hydroxytyrosol meets the Lipinski’s five principles of drug-like properties. With strong efficacy and pharmacological activity, HT has high drug-likeness degree. With good bioavailability, it can be easily absorbed by the gastrointestinal tract, though not absorbed by skin. Hydroxytyrosol has not only a strong potency and pharmacological activity, but also no liver toxicity and skin allergy. Tox data predicts that it has mutagenic potential, which may be the result of overreduction.

Key words: Olea europaea L., hydroxytyrosol (HT), ADEM/Tox, pharmacological activity