Asian Journal of Traditional Medicines
Asian Journal
Of Traditional Medicines

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›› 2006, Vol. 1 ›› Issue (3-4): 155-158.

• 论文 • Previous Articles     Next Articles

Steroidal Glycosides from Dioscorea septemloba and their Inhibitory Activity on Bone Resorbing

Jun Yin 1*; Yang Liu 2; Zhihui Liu 1; Xiaokang Wang 1; Yingjie Chen 1; and Shigetoshi Kadota 3   

  1. 1 Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China; 2 Shenyang Hongqi Pharmacy limited Inc., 6 Xinluo Street, Shenyang 110179, China; 3 Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan
  • Received:2006-01-01 Revised:2006-01-01 Online:2006-10-15 Published:2006-10-15
  • Contact: Jun Yin

Abstract: Four spirostane glycosides were isolated from the active part of water extract of Dioscorea septemloba, which showed antiosteoporotic activity. Their structures were identified as methylprotodioscin (1), trigofoenoside D-1 (2), glycoside D (3) and protogracillin (4) on the basis
of spectral methods. Among these compounds, 1 showed potent inhibition against bone resorption induced by parathyroid hormone in a bone organ culture system.

Key words: Dioscorea septemloba, spirostane glycosides, bone resorbing

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