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›› 2012, Vol. 7 ›› Issue (5): 236-245.

• Regular Articles • 上一篇    

Isolation of bioactive phytoconstituents from Achyranthes aspera Linn. with anti-hyperlipidemic activity

Brajesh K. Sharma 1, Deepa Iyer 1, Umesh K. Patil 2*   

  1. 1 VNS Institute of Pharmacy and Research Centre, Neelbud, Bhopal 462044, M.P., India 2 Peoples Institute of Pharmacy and Research Centre, Bhopal 462037, M.P., India
  • 收稿日期:2012-01-03 修回日期:2012-09-17 出版日期:2012-10-20 发布日期:2012-10-20

Isolation of bioactive phytoconstituents from Achyranthes aspera Linn. with anti-hyperlipidemic activity

Brajesh K. Sharma 1, Deepa Iyer 1, Umesh K. Patil 2*   

  1. 1 VNS Institute of Pharmacy and Research Centre, Neelbud, Bhopal 462044, M.P., India 2 Peoples Institute of Pharmacy and Research Centre, Bhopal 462037, M.P., India
  • Received:2012-01-03 Revised:2012-09-17 Online:2012-10-20 Published:2012-10-20
  • Contact: Umesh K. Patil

摘要： Phytochemical investigation of the aerial parts of Achyranthes aspera Linn. resulted in the isolation of octyl octadec-9-enoate
and heptacosan-14-β-ol for the first time from the plant. The structure of the component has been established on the basis of
spectral data analysis. Phytochemical screening revealed the presence of glycosides, tannins and alkaloids in ethanolic extract
of Acyhranthes aspera while chloroform fraction revealed the presence of sterols. The present study was undertaken to explore
the antihyperlipidemic effect of ethanolic extract of of Achyranthes aspera, its chloroform fraction, octyl octadec-9-enoate and
heptacosan-14-β-ol in Triton- induced hyperlipidemic rats. Animals were administered with i.p. injection of Triton WR 1339 at
dose of 400 mg/kg body weight. After 24 h. of Triton administration the ethanolic extract, its chloroform fraction, octyl octadec-
9-enoate and heptacosan-14-β-ol were administered orally at doses of 200 mg/kg body weight in rats. The extract, fraction and
heptacosan-14-β-ol inhibited the total cholesterol, triglycerides, low density lipoproteins level (LDL), and significantly increased
high density lipoprotein level (HDL). The results obtained suggest marked antihyperlipidemic activity of heptacosan-14-β-ol
compared to octyl octadec-9-enoate.

Abstract: Phytochemical investigation of the aerial parts of Achyranthes aspera Linn. resulted in the isolation of octyl octadec-9-enoate
and heptacosan-14-β-ol for the first time from the plant. The structure of the component has been established on the basis of
spectral data analysis. Phytochemical screening revealed the presence of glycosides, tannins and alkaloids in ethanolic extract
of Acyhranthes aspera while chloroform fraction revealed the presence of sterols. The present study was undertaken to explore
the antihyperlipidemic effect of ethanolic extract of of Achyranthes aspera, its chloroform fraction, octyl octadec-9-enoate and
heptacosan-14-β-ol in Triton- induced hyperlipidemic rats. Animals were administered with i.p. injection of Triton WR 1339 at
dose of 400 mg/kg body weight. After 24 h. of Triton administration the ethanolic extract, its chloroform fraction, octyl octadec-
9-enoate and heptacosan-14-β-ol were administered orally at doses of 200 mg/kg body weight in rats. The extract, fraction and
heptacosan-14-β-ol inhibited the total cholesterol, triglycerides, low density lipoproteins level (LDL), and significantly increased
high density lipoprotein level (HDL). The results obtained suggest marked antihyperlipidemic activity of heptacosan-14-β-ol
compared to octyl octadec-9-enoate.

Key words: octyl octadec-9-enoate, heptacosan-14-β-ol, anti-hyperlipidemic effect, LDL, HDL

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