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Two new lanostane type triterpenes isolated from the hepatoprotective active acetone extract of fruits of Luffa echinata Roxb.

Tanveer Alam 1, Bahar Ahmed 1, Lubna Najam 2, Shah A. Khan 3*   

  1. 1 Antihepatotoxic research lab, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard University, New Delhi-110062, India; 2 Department of Chemistry, DAV College, CCS university, Muzaffar Nagar, UP, India; 3 Department of Pharmacy, Oman Medical College, Muscat, Sultanate of Oman
  • 收稿日期:2015-05-25 修回日期:2015-12-21 出版日期:2016-06-20 发布日期:2016-06-24

Two new lanostane type triterpenes isolated from the hepatoprotective active acetone extract of fruits of Luffa echinata Roxb.

Tanveer Alam 1, Bahar Ahmed 1, Lubna Najam 2, Shah A. Khan 3*   

  1. 1 Antihepatotoxic research lab, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard University, New Delhi-110062, India; 2 Department of Chemistry, DAV College, CCS university, Muzaffar Nagar, UP, India; 3 Department of Pharmacy, Oman Medical College, Muscat, Sultanate of Oman
  • Received:2015-05-25 Revised:2015-12-21 Online:2016-06-20 Published:2016-06-24
  • Contact: Shah A. Khan, Department of Pharmacy, Oman Medical College, Muscat, Sultanate of Oman; Tel.: +00968-24504608(165); E-mail: shahalamkhan@ yahoo.com

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摘要： Two new lanostane type triterpenes, lanost 6(7),23(24)-diene-3,11,22trione-20,25-diacetoxy-2-β-16-α-diol (1) and lanost 1(2),6(7),23(24)-triene-3,11,22-trione-20,25-diacetoxy-2,16-α-diol (2) were isolated from the hepatoprotective active acetone fruit extract of Luffa echinata Roxb and their structures were characterized on the basis of spectroscopic and chemical evidences. The isolated compounds are reported in this species for the first time and are new analogs of cucurbitacin B and datiscacin, respectively

关键词: Luffa echinata, triterpene, lanostane, cucurbitaceae

Abstract: Two new lanostane type triterpenes, lanost 6(7),23(24)-diene-3,11,22trione-20,25-diacetoxy-2-β-16-α-diol (1) and lanost 1(2),6(7),23(24)-triene-3,11,22-trione-20,25-diacetoxy-2,16-α-diol (2) were isolated from the hepatoprotective active acetone fruit extract of Luffa echinata Roxb and their structures were characterized on the basis of spectroscopic and chemical evidences. The isolated compounds are reported in this species for the first time and are new analogs of cucurbitacin B and datiscacin, respectively

Key words: Luffa echinata, triterpene, lanostane, cucurbitaceae

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