A novel approach for quality control of Compound
Danshen Tablets by using Multi-wavelength highperformance
liquid chromatographic fingerprints and
chemometrics to predict the antioxidant activity

亚洲传统医药

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A novel approach for quality control of Compound Danshen Tablets by using Multi-wavelength highperformance liquid chromatographic fingerprints and chemometrics to predict the antioxidant activity

Jiao Chen, Guoxiang Sun*, Yue Yu

College of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, China

收稿日期:2017-09-06 修回日期:2017-11-11 出版日期:2017-12-20 发布日期:2017-11-11

A novel approach for quality control of Compound Danshen Tablets by using Multi-wavelength highperformance liquid chromatographic fingerprints and chemometrics to predict the antioxidant activity

Jiao Chen, Guoxiang Sun*, Yue Yu

College of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, China

Received:2017-09-06 Revised:2017-11-11 Online:2017-12-20 Published:2017-11-11
Contact: College of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, China; E-mail: gxswmwys@163.com; Tel.: +86-24-23986286.

摘要/Abstract

摘要： The objective of this paper was to establish an efficient method for quality control of Compound Danshen Tablets (CDST). A simple and reliable high-performance liquid chromatography (HPLC) method was developed both for multi-wavelength fusion fingerprint and quantitative determination. Off-line antioxidant assay was performed to predict the antioxidant activity of CDST using partial least squares (PLS) model. The present approach was powerful and reliable, which can be employed for comprehensively evaluate the quality consistency of traditional Chinese medicines (TCM).

关键词: antioxidant activity, Compound Danshen Tablets, content determination, multi-wavelength fusion fingerprint, Partial Least Squares

Abstract: The objective of this paper was to establish an efficient method for quality control of Compound Danshen Tablets (CDST). A simple and reliable high-performance liquid chromatography (HPLC) method was developed both for multi-wavelength fusion fingerprint and quantitative determination. Off-line antioxidant assay was performed to predict the antioxidant activity of CDST using partial least squares (PLS) model. The present approach was powerful and reliable, which can be employed for comprehensively evaluate the quality consistency of traditional Chinese medicines (TCM).

Key words: antioxidant activity, Compound Danshen Tablets, content determination, multi-wavelength fusion fingerprint, Partial Least Squares

Jiao Chen, Guoxiang Sun, Yue Yu. A novel approach for quality control of Compound Danshen Tablets by using Multi-wavelength highperformance liquid chromatographic fingerprints and chemometrics to predict the antioxidant activity[J]. 亚洲传统医药.

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亚洲传统医药

A novel approach for quality control of Compound Danshen Tablets by using Multi-wavelength highperformance liquid chromatographic fingerprints and chemometrics to predict the antioxidant activity

A novel approach for quality control of Compound Danshen Tablets by using Multi-wavelength highperformance liquid chromatographic fingerprints and chemometrics to predict the antioxidant activity

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