Flavonoids with cytotoxicities from the seeds of
Pongamia pinnata (L.) Pierre

亚洲传统医药 ›› 2020, Vol. 15 ›› Issue (4): 153-163.

• Regular Article • 上一篇下一篇

Flavonoids with cytotoxicities from the seeds of Pongamia pinnata (L.) Pierre

Wanru Jiang, Yuan Gao, Jiaxin Qi, Gang Chen, Di Zhou*, Ning Li*

Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China

收稿日期:2020-03-13 接受日期:2020-06-01 出版日期:2020-08-20 发布日期:2020-09-01

Flavonoids with cytotoxicities from the seeds of Pongamia pinnata (L.) Pierre

Wanru Jiang, Yuan Gao, Jiaxin Qi, Gang Chen, Di Zhou*, Ning Li*

Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China

Received:2020-03-13 Accepted:2020-06-01 Online:2020-08-20 Published:2020-09-01
Contact: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China; Tel.: +86-24-43520739; Fax: +86-24-31509368; E-mail: liningsypharm@163.com. E-mail:liningsypharm@163.com

摘要/Abstract

摘要： Twenty-eight compounds, including flavones (2, 4-5, 7-11), flavonols (1, 3, 6, 21, 22), flavanones (12-18), isoflavones (19, 20), chalcones (23, 24), phenylpropanoids (25, 26), and others (27, 28) were isolated from the ethanol extract of the seeds of Pongamia pinnata (L.) Pierre and identified on the basis of physic-chemical constants and spectral analysis (NMR, ECD, [α]2 0 D ). Among them, compounds 16, 18, 21, 23, 25 and 26 were obtained from the genus for the first time. The cytotoxicities of the purified flavonoids against H292 cells were evaluated using MTT assays. As a result, compounds 14 and 15 displayed moderate cytotoxicities.

关键词: Pongamia pinnata (L.) Pierre, constituent, flavonoids, cytotoxicities

Abstract: Twenty-eight compounds, including flavones (2, 4-5, 7-11), flavonols (1, 3, 6, 21, 22), flavanones (12-18), isoflavones (19, 20), chalcones (23, 24), phenylpropanoids (25, 26), and others (27, 28) were isolated from the ethanol extract of the seeds of Pongamia pinnata (L.) Pierre and identified on the basis of physic-chemical constants and spectral analysis (NMR, ECD, [α]2 0 D ). Among them, compounds 16, 18, 21, 23, 25 and 26 were obtained from the genus for the first time. The cytotoxicities of the purified flavonoids against H292 cells were evaluated using MTT assays. As a result, compounds 14 and 15 displayed moderate cytotoxicities.

Key words: Pongamia pinnata (L.) Pierre, constituent, flavonoids, cytotoxicities

Wanru Jiang, Yuan Gao, Jiaxin Qi, Gang Chen, Di Zhou, Ning Li. Flavonoids with cytotoxicities from the seeds of Pongamia pinnata (L.) Pierre[J]. 亚洲传统医药, 2020, 15(4): 153-163.

Wanru Jiang, Yuan Gao, Jiaxin Qi, Gang Chen, Di Zhou, Ning Li. Flavonoids with cytotoxicities from the seeds of Pongamia pinnata (L.) Pierre[J]. Asian Journal of Traditional Medicines, 2020, 15(4): 153-163.

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Flavonoids with cytotoxicities from the seeds of Pongamia pinnata (L.) Pierre

Flavonoids with cytotoxicities from the seeds of Pongamia pinnata (L.) Pierre

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