High performance thin layer chromatography as an effective tool for rapid screening of 5α-reductase inhibitors

亚洲传统医药 ›› 2021, Vol. 16 ›› Issue (4): 216-224.

High performance thin layer chromatography as an effective tool for rapid screening of 5α-reductase inhibitors

出版日期:2021-08-25 发布日期:2021-09-02

High performance thin layer chromatography as an effective tool for rapid screening of 5α-reductase inhibitors

Online:2021-08-25 Published:2021-09-02

摘要/Abstract

摘要： Benign prostatic hyperplasia (BPH) is a common disease in men, and is known to be related to 5α-reductase, which can affect steroid metabolism. Under the promotion of 5α-reductase, testosterone can be converted into dihydrotestosterone (DHT), and excessive DHT will cause related diseases. Since BPH seriously affects the quality of life of patients, it is essential to discover effective 5α-reductase inhibitors. In this study, the simple analytical method of high performance thin layer chromatography (HPTLC) was used to screen active compounds, and seven compounds with strong activity were screened out. This research will provide a reference for studying the material basis of drugs for the treatment of BPH.

关键词: 5α-reductase inhibitor, benign prostatic hyperplasia, HPTLC, steroid hormones, dihydrotestosterone

Abstract: Benign prostatic hyperplasia (BPH) is a common disease in men, and is known to be related to 5α-reductase, which can affect steroid metabolism. Under the promotion of 5α-reductase, testosterone can be converted into dihydrotestosterone (DHT), and excessive DHT will cause related diseases. Since BPH seriously affects the quality of life of patients, it is essential to discover effective 5α-reductase inhibitors. In this study, the simple analytical method of high performance thin layer chromatography (HPTLC) was used to screen active compounds, and seven compounds with strong activity were screened out. This research will provide a reference for studying the material basis of drugs for the treatment of BPH.

Key words: 5α-reductase inhibitor, benign prostatic hyperplasia, HPTLC, steroid hormones, dihydrotestosterone

Ruirong Zheng†, Mooseob Kim†, Zhengtao Wang, Li Yang. High performance thin layer chromatography as an effective tool for rapid screening of 5α-reductase inhibitors[J]. 亚洲传统医药, 2021, 16(4): 216-224.

Ruirong Zheng†, Mooseob Kim†, Zhengtao Wang, Li Yang. High performance thin layer chromatography as an effective tool for rapid screening of 5α-reductase inhibitors[J]. Asian Journal of Traditional Medicines, 2021, 16(4): 216-224.

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High performance thin layer chromatography as an effective tool for rapid screening of 5α-reductase inhibitors

High performance thin layer chromatography as an effective tool for rapid screening of 5α-reductase inhibitors

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