亚洲传统医药

本期目录

2022年, 第17卷, 第5期　刊出日期：2022-10-23 上一期   

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Uncovering the mechanism of Sophora flavescens in the treatment of glioma based on network pharmacology Jiaqi Niu, Qian Li, Jinling Jiang, Guodong Yao 2022 (5):  193-211.  摘要 ( 219 )   PDF(5288KB) ( 206 )   Glioma is a common primary intracranial tumor with high mortality and postoperative recurrence. Developing efficient therapies with lower toxicity is urgently needed. Sophora flavescens (SF) is a common Chinese medicine used to treat eczema, wet ulcers and itchy skin. Modern pharmacological studies have showed that SF has anti-glioma effects, but the mechanism of action remains unclear. This study aims to reveal the pharmacological mechanism of SF in treating glioma. The active components and related targets of SF were obtained from TCMSP. Genecard and Online Mendelian Inheritance in Man (OMIM) databases were used to explore the therapeutic targets for glioma. By making Venn diagram, we obtained 132 common targets of compounds and diseases. STRING databases and Cytoscape were used to construct diagrams of Protein-Protein Interaction (PPI) networks. Through the construction of PPI network, potential targets with degree value greater than the median were taken as core targets for further analysis. A total of 66 core targets were screened out. The degree values of TP53, HSP90AA1, MAPK1, and AKT1 were higher, indicating that these genes played important roles in this network. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were used to further discover the mechanism of active components in SF. Through enrichment analysis, it was found that the core targets were mainly enriched in PI3K/AKT signaling pathway, cell senescence related signaling pathway and IL-17 signaling pathway. In order to further explore the binding between active components and selected target, molecular docking was carried out. Finally, SwissADME was used to determine whether the compound could cross the blood-brain barrier. Based on network pharmacology, we speculated that matrine and formononetin in SF might inhibit PI3K/AKT signaling pathway and cellular senescence related signaling pathway by targeting AKT1, TP53, MAPK1 and other key targets. In summary, this study preliminarily explored the target and mode of action of SF in the treatment of glioma, laying the foundation for further research on its mechanism. 相关文章 | 计量指标

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Progress on chemical constituents and pharmacological effects of Piper nigrum L. Ye Chang, Yuxi Wang, Xiaoxiao Huang, Shaojiang Song 2022 (5):  212-225.  摘要 ( 177 )   PDF(1494KB) ( 248 )   Piper nigrum L., belonging to Piper genus of the Piperaceae family, is a medicinal and edible plant. Studies have shown that there are many chemical constituents in this plant, including alkaloids, lignans, steroids and other compounds. In addition, some chemical components of P. nigrum have potential values to treat cancer, inflammation and other diseases. Research progress on the chemical constituents and pharmacological effects of P. nigrum was reviewed in this study to better explore its potential medicinal value. 相关文章 | 计量指标

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The Genus Bletilla: A review of chemical constituents and pharmacological activities Wanyi Shi, Yuxi Wang, Xiaoxiao Huang 2022 (5):  226-243.  摘要 ( 160 )   PDF(1662KB) ( 170 )   Bletilla striata is the traditional medicine widely used to treat a series of diseases such as bleeding, burns and tumor. The congeners have similar effect. This study reviewed the recent research progress on the chemical components and pharmacological activities of the genus Bletilla. The review summarized over 160 compounds isolated from the plants of genus Bletilla, including phenanthrenes, diphenanthrenes, bibenzyls, flavonoids and quinones. The plants of genus Bletilla have potent bioactivities, such as hemostatic activity, effect of promoting wound healing, antitumor activity and anti-inflammatory activity. Although a lot of compounds have been isolated from the genus Bletilla, pharmacological studies have been limited to anti-inflammatory and antibacterial activities. 相关文章 | 计量指标

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Research review on the main chemical constituents and pharmacological activities of Viburnum awabuki Jingxian Ren, Zhuoyang Cheng, Xiaoxiao Huang, Shaojiang Song 2022 (5):  244-252.  摘要 ( 116 )   PDF(1598KB) ( 175 )   Viburnum awabuki (V. awabuki), belonging to the Viburnum genus, is an ideal tree species for landscaping. Phytochemical investigations of the V. awabuki have resulted in the isolation and identification of coumarins, lignans, sesquiterpenes, diterpenes and triterpenes. It has been reported that the extracts of V. awabuki have multiple pharmacological activities, including antitumor, anti-oxidant, plant growth inhibitory and neurite outgrowth-promoting activities. The research progress on the chemical constituents of V. awabuki and pharmacological activities were summarized in this review. 相关文章 | 计量指标