Asian Journal of Traditional Medicines
Asian Journal
Of Traditional Medicines

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›› 2006, Vol. 1 ›› Issue (1): 15-19.

• 论文 • Previous Articles     Next Articles

Comparison of the Effects of Long-term and Short-term Treatment of Powder from Soft-shell Turtle on Bone Loss and Reduction in Bone Strength in OVX Rats

Jun Yin*1; Zhihui Liu1; Subehan2; Junya Ueda2; Katsumichi Matsushige2; and
Shigetoshi Kadota2   

  1. 1 Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, China, 2 Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan
  • Received:2006-01-01 Revised:2006-01-01 Online:2006-02-15 Published:2006-02-15
  • Contact: Jun Yin

Abstract: The comparative effects of long-term and short-term treatment with the powder of soft-shell turtle
(Trionyx sinensis)( SST) on the proximal tibiae of ovariectomized (OVX) rats were investigated by scanning
bones using peripheral quantitative computed tomography (pQCT). Initially, oral administration of SST (100
and 500 mg/kg) 3 times weekly was carried out for 6 weeks without any effect on preventing bone loss except
for inhibiting the reduction in bone mineral density (BMD) in cancellous bone; then SST (100 and 200 mg/kg)
3 times weekly was administered for six months and in the high dose group, it prevented the reduction in bone
mineral content (BMC) in total bone, BMC and bone mineral density (BMD) in cortical bone and bone
strength indexes induced by OVX, in a dose-dependent manner without any side effects on the uterus.

Key words: Trionyx sinensis, antiosteoporotic activity, OVX, peripheral quantitative computed tomography.

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