Asian Journal
Of Traditional Medicines

Abstract: The present investigation is aimed to determine the optimal formulation and preparation technology of Yangzheng chewable tablet, which is composed of Coriolus Versicolor, Schisandrae Chinensis Fructus. The optimal extraction of one of the ingredients Schisandrae Chinensis Fructus extract (SCFE) was performed by the total lignans and crude polysaccharide content verifying. The optimal formulation and preparation technology was determined as following: weighted the SCFE and Coriolus Versicolor polysaccharide 24 g totally in proportion respectively, mixed uniformly after adding dextrin 18 g, lactose 3 g, mannitol 3 g, aspartame 0.4 g and citric acid 0.4 g, prepared wet granules through stainless steel sieve of 16 meshes, and dried the wet granules at 50 °C. Then the dry granules were passed through 20 mesh screen and added talc 0.2 g uniformly, followed by compressing into 90 tablets with a single punch tablet press and coating in opadry. The preparation technology was proved to be reasonable, feasible and stable according to the weight variation and taste.

Key words: Yangzheng chewable tablet, liver injury, preparation technology, quality control