Studies on the chemical constituents of Safflower (Carthamus tinctorius L.) and their tyrosinase inhibitory activity

Studies on the chemical constituents of Safflower (Carthamus tinctorius L.) and their tyrosinase inhibitory activity

Zhiyang Yan, Yuxi Wang, Xiaoxiao Huang*

Department of Natural Product Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China

Received:2017-02-25 Revised:2017-05-22 Online:2017-06-20 Published:2017-05-22
Contact: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd., Shenyang 110016, China; Tel.: +86-24-23986486; E-mail: xiaoxiao270@163.com.

Abstract

Abstract: Six compounds were isolated from the water extractive of Safflower (Carthamus tinctorius L.). Their structures were elucidated via sufficient analyses of the spectroscopic data, including 1 H NMR, 13C NMR and HRESIMS. All the isolated compounds were tested for inhibitory activity against tyrosinase to inspect their effect on melanogenesis. At the concentration of 100 μmol/ml, compound 1 and 4-6 possessed more potency, with the inhibition rate at 67.51%, 84.91%, 72.16%, 92.37%, respectively, compared to arbutin (54.34%). Compound 3 exhibited moderate inhibitory activity with the inhibition rate at 48.65%. Molecular docking was performed to investigate mechanism of inhibition.

Key words: Safflower, tyrosinase inhibitory activity, melanin, molecular docking

Zhiyang Yan, Yuxi Wang, Xiaoxiao Huang. Studies on the chemical constituents of Safflower (Carthamus tinctorius L.) and their tyrosinase inhibitory activity[J]. Asina Journal Of Traditional Medicines.

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Asian Journal
Of Traditional Medicines