亚洲传统医药
亚洲传统医药

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›› 2013, Vol. 8 ›› Issue (5): 135-146.

• Regular Articles • 上一篇    

Comprehensively quantify the complex herbal system by ultravioletand infrared spectra analyses coupled with combustion heat torecognize the quality consistency of herbal preparation

Lifeng Li , Guoxiang Sun*   

  1. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
  • 收稿日期:2013-07-01 修回日期:2013-12-04 出版日期:2013-10-20 发布日期:2013-10-20
  • 通讯作者: Guoxiang Sun

Comprehensively quantify the complex herbal system by ultravioletand infrared spectra analyses coupled with combustion heat torecognize the quality consistency of herbal preparation

Lifeng Li , Guoxiang Sun*   

  1. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
  • Received:2013-07-01 Revised:2013-12-04 Online:2013-10-20 Published:2013-10-20
  • Contact: Guoxiang Sun

摘要： Spectral fingerprint including ultraviolet (UV) and Fourier transform infrared (FT-IR) and combusion heat analysis, potential
analytic techniques for rapid screening and elementary quality judgement were employed and compared for discriminating
Ginkgo tablets (GT) from different commercial brands. The systematic quantified fingerprint method (SQFM) was applied and
compared with principal component analysis (PCA) and hierarchical clustering analysis (HCA) respectively for above testing
methods. According to the comparison related to different analyitcal tools, the rationality of combination UV with IR fingerprints
was satisfactorily validated by combusion heat. It indicated classification methods assayed, PCA and HCA enabled us to make
a good discrimination; but they failed to present a detailed quality difference except for obvious unqualified ones instead of
the SQFM. And qualitative similarity analysis by the SQFM is poor to lead to a evident discrimination between samples. So
comprehensively quantified outcomes were finally presented as follows: sample S4 and S8 were thought as outliers while S1 and
S12 might be worse than the rest in the extent of our present work. Combination of multiple analytical methods with various data
handling ways is useful for the overall quality evluation of herbal medicine or their preparations.

Abstract: Spectral fingerprint including ultraviolet (UV) and Fourier transform infrared (FT-IR) and combusion heat analysis, potential
analytic techniques for rapid screening and elementary quality judgement were employed and compared for discriminating
Ginkgo tablets (GT) from different commercial brands. The systematic quantified fingerprint method (SQFM) was applied and
compared with principal component analysis (PCA) and hierarchical clustering analysis (HCA) respectively for above testing
methods. According to the comparison related to different analyitcal tools, the rationality of combination UV with IR fingerprints
was satisfactorily validated by combusion heat. It indicated classification methods assayed, PCA and HCA enabled us to make
a good discrimination; but they failed to present a detailed quality difference except for obvious unqualified ones instead of
the SQFM. And qualitative similarity analysis by the SQFM is poor to lead to a evident discrimination between samples. So
comprehensively quantified outcomes were finally presented as follows: sample S4 and S8 were thought as outliers while S1 and
S12 might be worse than the rest in the extent of our present work. Combination of multiple analytical methods with various data
handling ways is useful for the overall quality evluation of herbal medicine or their preparations.

Key words: spectral fingerprint, systematic quantified fingerprint method, chemometrics, combusion heat, Ginkgo Tablets

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