亚洲传统医药

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2013年, 第8卷, 第5期　刊出日期：2013-10-20 上一期    下一期

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Evaluation of galactagogue and antioxidant activitiesof the root extract of Euphorbia fusiformis Sumit Manna;Tapas K. Sur;Tapan Seal;Anirban Roy * 2013 (5):  119-128.  摘要 ( 545 )   Present communication deals with antioxidant activity of acetone and methanol extracts and evaluation of galactagogue activity of alcoholic extract of the roots of Euphorbia fusiformis, a rare medicinal herb traditionally used by the Santal tribe of Gonpur forest area, West Bengal, India. Phenolic content was estimated following Folin-Ciocalteu procedure. Flavanoids and flavonols content were also measured using standard protocols. 1, 1 diphenyl-2-picrylhydrazyl radical scavenging effect of the two different extracts were determined spectrophotometrically. Fifteen lactating rats were equally distributed into three groups. Control group rats were treated with 2 ml/kg distilled water, Group II and III rats were orally administered 250 and 500 mg/kg body weight, respectively, of ethanolic extract of the root of Euphorbia fusiformis from 3rd to 15th day of parturition. On 16th day, blood samples from mother rats were collected. Glycogen and total protein content in mammary gland and serum prolactin were estimated. Highest phenol content and radical scavenging with IC50 = 0.240±0.001 mg dry material was found in acetone extract of plant. Methanol extract contain a very good amount of flavanoids and flavonols. Alcoholic extract significantly increases milk yield, pups’ body weight, glycogen and protein content of mammary gland tissue, and serum prolactin, compared to control animals. Greater amount of phenolic compounds leads to more potent radical scavenging effect as shown by acetone extract of plant. Euphorbia fusiformis possesses significant antioxidant activity, and the bioactive constituents stimulate secretion/ regulation of prolactin hormone and thereby may regulate the formation of milk. 相关文章 | 计量指标

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Acute and sub-chronic oral evaluation of Qinlian oral liquid Jingjing Zhou;Zhe Zhao;Yu wang;Na Han;Zhihui Liu;Jun Yin * 2013 (5):  129-134.  摘要 ( 495 )   The present investigation was carried out to evaluate the safety of Qinlian oral liquid. In the acute toxicity study, a maximum single dose of 30 ml/kg of Qinlian oral iquid was given orally to healthy rats (n=12; 6 males and 6 females). There was no mortality or other signs of toxicity during 14 day observation period. Furthermore, no significant alteration either in relative organ weights or their histology was discernible at terminal autopsy. In the 90-day subchronic study, Qinlian oral liquid was administered to rats in high, medium and low doses (10 ml/kg, 3.2 ml/kg, 1 ml/kg), A control group of rats received normal saline only. The body weight of the rats, their food consumption, behavior, hematological data as well as the viscera index of important organs were normal. The high dose of animal of pathology takes place imperceptibly. Macroscopic and histopathological observations found no abnormalities. The medium dose (3.2 ml/kg) of Qinlian oral liquid is the maximum safe dose (it produces no adverse reactions). 相关文章 | 计量指标

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Comprehensively quantify the complex herbal system by ultravioletand infrared spectra analyses coupled with combustion heat torecognize the quality consistency of herbal preparation Lifeng Li;Guoxiang Sun* 2013 (5):  135-146.  摘要 ( 485 )   Spectral fingerprint including ultraviolet (UV) and Fourier transform infrared (FT-IR) and combusion heat analysis, potential analytic techniques for rapid screening and elementary quality judgement were employed and compared for discriminating Ginkgo tablets (GT) from different commercial brands. The systematic quantified fingerprint method (SQFM) was applied and compared with principal component analysis (PCA) and hierarchical clustering analysis (HCA) respectively for above testing methods. According to the comparison related to different analyitcal tools, the rationality of combination UV with IR fingerprints was satisfactorily validated by combusion heat. It indicated classification methods assayed, PCA and HCA enabled us to make a good discrimination; but they failed to present a detailed quality difference except for obvious unqualified ones instead of the SQFM. And qualitative similarity analysis by the SQFM is poor to lead to a evident discrimination between samples. So comprehensively quantified outcomes were finally presented as follows: sample S4 and S8 were thought as outliers while S1 and S12 might be worse than the rest in the extent of our present work. Combination of multiple analytical methods with various data handling ways is useful for the overall quality evluation of herbal medicine or their preparations. 相关文章 | 计量指标