亚洲传统医药

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2018年, 第13卷, 第2期　刊出日期：2018-04-20 上一期    下一期

Regular Article

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Phytochemical and chemotaxonomic studies on the Trillium tschonoskii Maxim. Ting Yan, Manhuayun Zhai, Jingming Jia 2018 (2):  61-67.  摘要 ( 311 )   PDF(861KB) ( 482 )   Chemical investigation of the ethanol extract from the rhizomes of Trillium tschonoskii Maxim, led to the isolation of sixteen compounds (1-16), including thirteen steroidal saponins (1-13), one sterone (14), one alkaloid (15) and one oligosaccharide ester (16). Among them, compounds 5, 10 and 11 are reported here for the first time from T. tschonoskii, and compounds 1, 7-9 and 15 are firstly isolated from Trillium genus. The research data indicate that the existence of steroidal saponins might be regarded as valuable and useful chemotaxonomic markers for further classification and subdivision of the genus of Trillium. 相关文章 | 计量指标

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Network pharmacology-based virtual screening of natural products from the samara of Ailanthus altissima (Mill.) Swingle for identification of anticancer therapeutics Peng Zhao,Zhiyang Yan,Danqi Li,Xiaoxiao Huang 2018 (2):  68-76.  摘要 ( 331 )   PDF(1169KB) ( 568 )   Natural products play a more and more vital role in the discovery of new drug molecules and they are also used for the development of novel anticancer drugs. Literature review shows that the samara of Ailanthus altissima (Mill.) Swingle may possess strong inhibitory efficacy against various types of cancer cells. Therefore a study was carried out to identify selective anticancer agents from the samara. In this report, we employed a docking weighted network pharmacological approach to understand the anticancer potentiality of the samara of Ailanthus altissima (Mill.) Swingle. against six types of cancers. And three compounds with different structure types, namely 1-O-β-D glucopyranosyl-(2S,3R,4E,9E)-2-(2'R hydroxyhexadecenoylamino)-4,9-octadecadiene-l,3-diol (FO45), quercetin 3-O-β-D-glucopyranoside (FF39), 6α-hydroxystigmast-4-en-3-one (FS5), were predicted to have potential activities for cancer target proteins. FO45 was found to have maximum interactions with 45 liver cancer targets in terms of docking weighted network pharmacological analysis. We believe that our present study may provide important clues for finding novel lead compounds for cancer. 相关文章 | 计量指标

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Phenolic compounds from Pithecellobium clypearia with tyrosinase inhibitory activity Han Zhang, Zhiyang Yan, Yuxi Wang, Xiaoxiao Huang 2018 (2):  77-83.  摘要 ( 387 )   PDF(675KB) ( 513 )   A series of phenolic acids from Pithecellobium clypearia have been isolated. Their stereochemical structures were determined by comprehensive spectroscopic data analyses. The tyrosinase inhibitory activity of all compounds was tested to investigate the effects on their melanogenesis. The result showed that compounds 1 and 5 exhibited higher tyrosinase inhibitory activities (inhibitory ratios at 92.15%, 93.57%, respectively) than the reference compound, arbutin (57.35%). Docking experiments were carried out in order to study the interactions between these compounds and mushroom tyrosinase. 相关文章 | 计量指标

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Prediction of the active ingredients and potential targets of Chinese herb Juglans mandshurica Maxim. against liver cancer based on network pharmacology Yeqing Du, Rui Guo, Weiyu Zhou, Xiaoxiao Huang, Shaojiang Song 2018 (2):  84-93.  摘要 ( 254 )   PDF(1021KB) ( 608 )   Juglans mandshurica Maxim. belongs to Juglans genus in the Juglandaceae family. It is shown from modern researches that J. mandshurica had multiple activities, and the anti-tumor activity of extracts of J.mandshurica was investigated by most researchers. However, few studies were did about anti-tumor effect of human hepatoma cells, and no systematic studies were did on anti-tumor mechanism. Therefore, it is of great significance to investigate the anti-hepatoma active ingredients of J. mandshurica from the perspective of systemic biology with the help of network pharmacology. In order to find active ingredients and identify the major targets of molecule, we used molecular docking and network pharmacology to construct molecule-target network maps. The results showed that bediarylheptanoids were the main active compounds with anti-hepatoma effect in the plants of J. mandshurica, and suggested that there were ten key targets of liver cancer. In order to illustrate the mechanism between compounds and targets, we used DS software to analyze intermolecular forces between three compounds (H79, H78, H84) and aceDAF-12. According to the results of DS, the mechanism of interaction between compounds and targets was clarified and revealed at the molecular level. 相关文章 | 计量指标