亚洲传统医药

本期目录

2018年, 第13卷, 第3期　刊出日期：2018-06-20 上一期    下一期

Regular Article

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Screening of potential active compounds in Eurycoma longifolia against hepatic carcinoma by Network pharmacology Chunxin Zou, Wenyu Zhao, Zhiyang Yan, Xiaoxiao Huang, Shaojiang Song, Xiaobo Wan 2018 (3):  95-102.  摘要 ( 248 )   PDF(894KB) ( 514 )   Eurycoma longifolia as one of the most well-known folk medicines, belongs to Eurycoma genus of Simaroubaceae family. Pharmacology researches reported that E. longifolia has been widely used for its anticancer, antimalarial, aphrodisiac, antiinflammatory, and antibacterial activities. However, its system-level researches of drug-target associations is not enough. Here we employed molecular docking and network pharmacology methods to predict the effective compositions and its potential target proteins. Eight compounds in E. longifolia belonging to squalene derivatives, biphenyl neolignans and alkaloids were predicted to have potential activity for liver-cancer target proteins. Meanwhile, we analyzed the interaction mode of these active components with nuclear receptor coactivator 2 (3up3), which may be the pivotal target on inhibiting liver cancer. This article is presented to explore the active ingredients of E. longifolia and provide crucial material for the further research and development of the plant. 相关文章 | 计量指标

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Molecular targets of Gelsemium elegans: a study of hepatoma based on network pharmacology Shuangshuang Li, Lingzhi Li 2018 (3):  103-109.  摘要 ( 252 )   PDF(1514KB) ( 486 )   Gelsemium elegans (Loganiaceae), a well-known toxic vine belonging to Gelsemium genus of Loganiaceae family, has historically been used in traditional Chinese medicine for treatment of pain, spasticity, skin diseases and malignant tumors. Recently, the injection of the crude alkaloids from G. elegans has been used clinically to treat terminal esophageal and hepatocellular carcinoma (HCC). However, the underlying molecular mechanisms of compounds remain unclear. This study aims to ascertain molecular targets of compounds from plants about HCC based on network pharmacology, and six compounds, namely Gelsemiol-1-glicoside (97), Yohimbane Alkaloid 9 (67), Ethyl ferulate (113), Gelsemiol-3-glicoside (98), Eleganosides A (124) and Foliasalacioside B1 (126), were predicted to have potential activities for HCC target proteins. Then these compounds with potential effects were evaluated by predicting the b-Raf inhibitory activity, thereby establishing a research method for treatment of plants. Network pharmacology method was utilized to construct the active ingredient-target networks of the plant that were responsible for the beneficial effects against HCC. These attempts may offer several new insights to understand the pharmacological properties of G. elegans and provide crucial material for their further development and research. 相关文章 | 计量指标

Review

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Amide Alkaloids from the genus Piper: A Review of its Phytochemistry Weiyu Zhou, Ming Bai, Xiaoxiao Huang, Shaojiang Song 2018 (3):  110-126.  摘要 ( 407 )   PDF(1713KB) ( 867 )   The genus Piper is a large genus of flowering plants, belonging to the Piperaceae family. Phytochemical investigations of the genus Piper have resulted in the isolation of alkaloids, lignans, flavones, unsaturated amides, aristolactams, monoterpenes, sesquiterpenes, ketones, propenylphenols, chalcones, long and short chain esters, arylpropanoids and aldehydes. Researches have shown that the most significant chemical constituents of the genus Piper are amide alkaloids. They have multiple biological activities and a good development prospect, which has been closely concerned by researchers. This study is going to make an overview of the amide alkaloids of this genus, aiming at its further development and potential value. 相关文章 | 计量指标

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Research review on the main chemical constituents and pharmacological effects of the samara derived from Ailanthus altissima (Mill.) Swingle Peng Zhao, Zhiyang Yan, Rui Guo, Xiaoxiao Huang 2018 (3):  127-133.  摘要 ( 228 )   PDF(1026KB) ( 651 )   The samara of Ailanthus altissima (Mill.) Swingle., belonging to Ailanthus genus of Simaroubaceae family, is widely used as the common Chinese herbal medicine in folk. As a traditional medicinal agent, a wide spectrum of chemical constituents have been isolated from the samara, including steroids, triperpenoids, lignans, phenolic acids, quassioids, flavonoids and flavone glycosides. Its powder can be used as medicines for dysentery, metrorrhagia, ascariasis and hemostasis with astringents. The research shows that the samara has multiple activities and good development prospect, which has attracted a wide attention. Hence, this report is presented as a review centered on chemical constituents and pharmacological activities of the samara, aiming at its further development and potential as anticancer agents. 相关文章 | 计量指标