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Production of small molecules by an endophytic fungus,
Neofusicoccum parvum from the fruits of
Elaeocarpus serratus
Dilhara Dissanayake, N. Savitri Kumar, N.K.B. Adikaram, Lalith Jayasinghe, Hiroshi Araya, Yoshinori Fujimoto
2020 (2):
47-54.
摘要
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Neofusicoccum parvum, an endophytic fungus isolated from Elaeocarpus serratus (Ceylon Olive; family Elaeocarpaceae), was
grown for 3 weeks in potato dextrose broth. Chromatographic separation of the ethyl acetate extracts from the culture filtrate
and mycelium over silica gel, Sephadex LH-20 and preparative thin layer chromatography furnished (R)-7-hydroxymellein
(1), (3R,4R)-4-hydroxymellein (2), (3R,4S)-4-hydroxymellein (3), (R)-5-hydroxymellein (4), (R)-mellein (5), (3R,4R)-4,7-
dihydroxymellein (6), (6R,7S)-dia-asperlin (7), CJ-14445 (8) and 13,14,15,16-tetranorlabd-7-ene-19,6β:12,17-diolide (9). The
structures of known compounds 1–9 were determined by spectroscopic methods and comparison with reported data. This is
the first report of the isolation of an endophytic fungus from E. serratus, and the isolation of compounds 1, 4, 6, 8 and 9 from N.
parvum. It is important to note that compounds 1–7 are small molecules with an oxygen heterocyclic ring system. These compounds
can be used as starting materials in the synthesis of pharmaceutically important large molecules with oxygen heterocyles.
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