亚洲传统医药

本期目录

2018年, 第13卷, 第5期　刊出日期：2018-10-20 上一期    下一期

Regular Article

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Antioxidant chemical constituents from the herb of Plantago asiatica L. Xue Lu, Na Han, Huijing Liu, Zhihui Liu, Jun Yin 2018 (5):  175-183.  摘要 ( 338 )   PDF(837KB) ( 468 )   N-BuOH fraction from aqueous extract of the herb of Plantago asiatica L. showed the best antioxidant activity by bioassay guided fractionation. Using column chromatography, fourteen compounds were isolated from the active fraction, including adenosine (1), uridine (2), thymidine (3), adenine (4), megastigmane-7-ene-3, 5, 6, 9-tetrol (5), 9-hydroxy-megastigman-4, 7-dien- 3-one-9-O-β-D-glucopyranoside (6), 2-(3, 4-dihydroxy)-phenyl-ethyl-O-β-D-glucopyranoside (7), plantainoside D (8), darendoside B (9), Savaside A (10), oct-1-en-3-ol-O-β-D-glucopyranosyl-(1″→2′)-O-β-D-glucopyranoside (11), linarin (12), syringaresinol-4'- O-β-D-glucopyranoside (13) and caprolactam (14), chemical structures of these compounds were identified on the basis of NMR spectroscopy evidence. Among them, compound 12 was obtained from this plant for the first time, and compound 5, 6, 7, 9 and 10 were isolated from the genus of Plantago firstly, moreover, compound 5 and 6 belong to the kind of megastigmane, which was not found in the Plantago genus before. Moreover, by using DPPH radical scavenging assay, we knew that compound 1 exhibited the antioxidant activity. 相关文章 | 计量指标

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Network pharmacology-based virtual screening of the active ingredients and potential targets from amide alkaloids of Piper genus against Alzheimer’s disease Weiyu Zhou, Ming Bai, Xiaoxiao Huang, Shaojiang Song 2018 (5):  184-191.  摘要 ( 482 )   PDF(1313KB) ( 482 )   Alzheimer’s disease (AD) is a genetically complex neurodegenerative disease and its pathological mechanism has not been fully discovered. In the current study, we have examined the medicinal effect of amide alkaloids of the Piper genus in the treatment of AD using network pharmacology. High-confidence level networks consisting of compound-protein target and protein targetpathway association were developed and the potential active amide alkaloids of the Piper genus, the potential target proteins and the key pathways were predicted by network pharmacology models. Overall, this approach provided a novel strategy to explore the role of amide alkaloids of the Piper genus in the treatment of AD from a holistic perspective. 相关文章 | 计量指标

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Virtual Screening of Active Compounds and Potential Targets from Harrisonia perforata (Blanco) Merr. against Liver Cancer Based on Network Pharmacology Shifang Li, Ming Bai, Xiaoxiao Huang, Shaojiang Song 2018 (5):  192-199.  摘要 ( 355 )   PDF(1134KB) ( 544 )   Traditional Chinese Medicine plays an increasingly important role in cancer treatment for the property of the complex components and multi-targets. Harrisonia perforata, belonging to Simarubaceae family, was proved to be effective to cure cancer, but the action mechanism is unclear. In this paper, we utilized molecular docking and network analysis to find out the active ingredients of H. perforata and the potential target proteins involved in liver cancer, which is meaningful for the further research of liver cancer. 相关文章 | 计量指标

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The genus Crataegus: a review of phytochemistry and pharmacology perspectives Jie Wang, Zhiyang Yan, Le Zhou, Xiaoxiao Huang, Shaojiang Song 2018 (5):  200-213.  摘要 ( 387 )   PDF(3439KB) ( 517 )   Plants of the genus Crataegus are widely distributed in North America and China. Edwards et al. reported the phytochemicals and pharmacology of Crataegus species in 2012. From 2012 to 2017, numerous articles have been published on the chemical constituents and pharmacologic effects of the genus Crataegus. To review chemical and pharmacologic advances and discuss the potential prospects for future investigation, the report summarized over 150 compounds isolated from Crataegus species, including flavonoids, triterpenoids, terpenes, lignans, hydroxycinnamic acids and phenols. These compounds exhibited wide range of bioactivities including antoxidant, anti-inflammatory, anti-tumor and anti-thrombotic activities. 相关文章 | 计量指标