亚洲传统医药

本期目录

2017年, 第12卷, 第6期　刊出日期：2017-12-20 上一期    下一期

Review

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Research progress on biotransformation of monoterpenes by Aspergillus niger Siyu Hu, Peizhi Zou, Hongtao Yang, Dali Meng, Yu Chen 2017 (6):  235-239.  摘要 ( 282 )   PDF(609KB) ( 1046 )   Aspergillus niger is a widespread aerobic fungus that has been used for many different biotransformation of natural products. Monoterpenes, commonly used in pharmaceutical products, are those containing two isoprene unit terpene molecules and molecular derivatives. They are widespread in higher plants secrete tissue, and show a variety of biological activities. In this review, we summarize a number of processes that have been developed for the transformation of monoterpenes by the cultures of Aspergillus niger, and these results could lay the foundation for identifying new drug leads in the future. 相关文章 | 计量指标

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Research review on the main chemical components of Brucea javanica (L.) Merr Yeqing Du, Zhuoyang Cheng, Peng Zhao, Xiaoxiao Huang, Shaojiang Song 2017 (6):  240-249.  摘要 ( 354 )   PDF(1085KB) ( 1185 )   Brucea javanica (L.) Merr, belonging to Simaroubaceae family, is one species of the genus Brucea. The seeds, roots, leaves, fruits, stems and twigs of this plant had been used as a folk medicine for the treatment of various types of diseases. It is reported that there are kinds of chemical components in B. javanica. The main chemical components of this plant include quassinoids, triterpenoids and alkaloids. In this review, we summarized the researches on the chemical components and listed the main compounds isolated from the B. javanica. 相关文章 | 计量指标

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Treatment Mechanisms of Traditional Chinese Medicines for Liver Fibrosis Ming Song, Mengyue Zhang, Xin Wu 2017 (6):  250-259.  摘要 ( 292 )   PDF(718KB) ( 938 )   Liver fibrosis is a condition of abnormal proliferation of connective tissue due to various types of chronic liver injury. Evidence indicates that some traditional Chinese medicines are more effective to treat liver fibrosis clinically. In this review, the treatment mechanisms of traditional Chinese medicines for liver fibrosis are reviewed. We focus on traditional Chinese medicines against liver fibrosis in inhibition of viral replication, inhibiting hepatic stellate cell proliferation, anti-oxidation actions and regulation of cytokines. Evidence indicates that some traditional Chinese medicines are more effective to treat liver fibrosis, and the treatment mechanism of a traditional Chinese medicine for liver fibrosis may not be independent, but the combined effect. Additionally, a strict quality control of traditional Chinese medicines is critical for pharmacological, clinical and in-depth mechanism studies. 相关文章 | 计量指标

Regular Article

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Anti-inflammatory, analgesic activity and acute toxicity of Duzhong Yaozhui Pill Panpan Wang, Na Han, Mingshu Han, Zhihui Liu, Ping Shao, Zehai Song, Jun Yin 2017 (6):  260-266.  摘要 ( 292 )   PDF(622KB) ( 953 )   Duzhong Yaozhui Pill (DYP) as an orthopaedic medicine, it was evaluated in experimental models of inflammation, analgesic and toxicity. Xylene-induced ear edema in mice was used to assess anti-inflammation activity and analgesic was determined by acetic acid induced writhing in mice. Compared with control group, DYP exhibited significantly (p<0.05) anti-inflammatory effect through inhibiting ear edema caused by xylene with dose dependent manner. Compared with control group, DYP at the dosages of 2.36 mg/kg, 4.72 mg/kg showed significantly (p<0.05) analgesic activity by decreasing the mice writhing induced by acetic acid with dose dependent manner. The positive drug (Wantong Jingu Table) also presented anti-inflammatory and analgesic activity. In toxicity assays, male and female mice were given by gavage at the maximum dosage of DYP and observed indicators including clinical signs, animal mortality and the change of animal body weight. It was found that DYP was safe at dose of 42 g/kg and no mortality was shown even after 14 days of DYP administration. And the mice weight was gradually increased. This study gives support to the application of DYP in clinical. 相关文章 | 计量指标

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Study on the neurotoxicity of Strychni Semen and compatibility and detoxicity mechanism Xue Gao, Yaqiong Li, Sheng Chang, Hang Chang, Xiaojiao Zheng, Na Han, Zhihui Liu 2017 (6):  267-276.  摘要 ( 324 )   PDF(689KB) ( 1064 )   Strychni Semen has anti-tumor, analgesia, anti-inflammatory and anti-angiogenesis effects, but the clinical use of Strychni Semen is limited by its narrow therapeutic dose. The neurotoxicity caused by Strychni Semen and its major toxic constituents, strychnine and brucine, was reported in many clinical cases. The serious neurotoxicity effects caused by Strychni Semen lead to various symptoms. Its toxic components could pass through blood-brain barrier which might cause neuro-structural, neurofunctional, and neuro-behavioral changes. In this review, the potential neurotoxicity mechanisms and compatibility attenuation are summarized by searching a lot of literatures from 1962 to 2017 which not only providing the basis to future studies of herb medicines toxicity, but also reasonable proposes to clinical application of compatibility and detoxicity on Strychni Semen. 相关文章 | 计量指标

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Tyrosinase inhibitory compounds from safflower Zhiyang Yan, Peng Zhao, Xiaoxiao Huang 2017 (6):  277-285.  摘要 ( 255 )   PDF(869KB) ( 1015 )   Long term investigation on chemical constituents of safflower result in the isolation of 11 compounds from its water extractive. Their structures were determined by comprehensive spectroscopic data analyses. To evaluate their effect on melanogenesis, the obtained substances were evaluated for their inhibitory activity against tyrosinase and compounds 2, 4 and 7 exhibited outstanding inhibition, with inhibitory ratios at 91.3%, 87.1% and 95.0% at 100 mM, compared to the positive control arbutin (54.3%). The combination modes between compounds and tyrosinase were reasonably deduced by molecular docking. 相关文章 | 计量指标

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A novel approach for quality control of Compound Danshen Tablets by using Multi-wavelength highperformance liquid chromatographic fingerprints and chemometrics to predict the antioxidant activity Jiao Chen, Guoxiang Sun, Yue Yu 2017 (6):  286-302.  摘要 ( 308 )   PDF(1473KB) ( 2002 )   The objective of this paper was to establish an efficient method for quality control of Compound Danshen Tablets (CDST). A simple and reliable high-performance liquid chromatography (HPLC) method was developed both for multi-wavelength fusion fingerprint and quantitative determination. Off-line antioxidant assay was performed to predict the antioxidant activity of CDST using partial least squares (PLS) model. The present approach was powerful and reliable, which can be employed for comprehensively evaluate the quality consistency of traditional Chinese medicines (TCM). 相关文章 | 计量指标

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Network pharmacology-based prediction of the active ingredients and potential targets of alkaloids in Simaroubaceae plants for the application to treat cancer Peng Zhao, Danqi Li, Zhiyang Yan, Xiaoxiao Huang 2017 (6):  303-311.  摘要 ( 318 )   PDF(1306KB) ( 1054 )   Plant-derived natural products play a vital role in the discovery of new drug molecules and could be used for development of novel therapeutic drugs for a specific disease target. Literature review suggested that the plants of Simaroubaceae show strong inhibitory efficacy against various types of cancer cells. Therefore, it is necessary to identify selective anticancer agents from this family. The present studies of anticancer active ingredients in the Simaroubaceae family mainly focus on quassinoids in the genus Brucea, and the anticancer activities of the alkaloids are not attractive to the researchers. To illuminate the anti-cancer activities of alkaloids from the family Simaroubaceae, a compound database based on the methods of network pharmacology prediction was established in this paper by constructing the compound-cancer target network. According to the analysis of the model, the most effective anticancer compounds in the plants of the family Simaroubaceae might be bis-β-carboline alkaloid (Quassidines D), and the most potential targets might be EGFR and Hsp90. We believe that our present study is useful and may provide important clues for novel antineoplastics. 相关文章 | 计量指标