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Evaluation of the quality consistency of Compound Liangmianzhen tablets using HPLC fingerprints for antioxidant activity Linyan Sun, Guoxiang Sun, Jing Zhang Asina Journal Of Traditional Medicines

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Role of caspase-9 in anti-tumor activities by active compounds from natural products Qiang Zhang, Zhenan Zhang, Hui Liu, Shijie Cao, Yuanhao Lv, Hongrui Cao,Yanfei P Asina Journal Of Traditional Medicines

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Evaluating the quality consistency of compound Liangmianzhen buccal tablets during accessories replacement by HPLC/UV related with its active profiling and UV dissolution profiles Yue Yu, Hanxiao Chi, Guoxiang Sun, Fangliang Yang, Wanyang Sun, Jiayue Hu, Yanhua Zhang Asian Journal of Traditional Medicines    2020, 15 (1): 8-23.   Abstract （341）      PDF（pc） （2255KB）（2060）       Knowledge map    Compound Liangmianzhen buccal tablet is a drug that exhibits notable effect on cough and diphtheria. Since the accessory has been changed, along with the difficulties in traditional Chinese drug-evaluation, it is imperative to set up a reliable method to evaluate the drug and ensure the quality consistency. First, the content of the Compound Liangmianzhen buccal tablets reflected by fingerprints were evaluated by the comprehensive linearly quantified fingerprint method and systematic quantified fingerprint method, in which thirteen fingerprint peaks was selected and gallic acid was chosen as the reference peak. The results of the two methods showed all batches in grades 1–3 of above good level with the qualitative similarities of Sl and Sm above 0.90, and the quantitative ones of Pl% and Pm% from 80%–120%, indicating all samples far qualified. Second, the measurement of antioxidant effect based on DPPH free radical clearance test has demonstrated the consistency between the old prescription group and the new ones and further dug up the major antioxidant compositions. Third, dissolution profiles at 190 to 400 nm that evaluate the curative effect consistency were evaluated by f2 and the correlation of the dissolution curve. In conclusion, the combination of 3 kinds of analysis methods can comprehensively assess the quality of the traditional Chinese drug and be served as a routine procedure to evaluate the herbal medicine consistency. Related Articles | Metrics

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A systematic quantitative method for quality evaluation of Bupleurum chinense DC. based on multi-wavelength fusion fingerprint combined with multivariate chemometrics Ye Zhu, Ran Wen, Yaping Yu, Wei Wei, Guoxiang Sun Asina Journal Of Traditional Medicines

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Comprehensive quality control of Xue Fu Zhu Yu Pillbased on chromatographic fingerprints and antioxidantactivity combined with chemometrics methods Yaning Gao;Guoxiang Sun *;Ping Wang;Jiayue Gao null    2015, 10 (2): 23-38.   Abstract （389）            Knowledge map    High-performance liquid chromatographic fingerprint technique was adopted to monitor the quality of traditional Chinese medicine (TCM) Xue Fu Zhu Yu Pill (XFZYP). The novel 24 levels of systematic quantified fingerprint methods (SQFMs) were set up, and 230 nm HPLC fingerprints as well as 6 maker components were determined and identified, in combination of antioxidant activity detected by DPPH. Chromatographic fingerprints resolution information index RI was employed to screen the optimized condition for sample analysis, and chemometrics was used to extract more information from the data. By 24 levels SQFMs, the samples show accepted quality of 1~4. With help of multi-criteria decision making ranking methods (MCDM) PROMETHEE (Preference Ranking Organization Method for Enrichment Evaluation) and GAIA (Geometrical Analysis for Interactive Aid), the XFZYP samples from two manufactures were efficiently differentiated and classified. Furthermore, the antioxidant activity results expressed as IC50 were further analyzed by PLSR (Partial Least Squares Regression) to establish spectrum-efficacy relationship and to predict the IC50. The work indicates that the proposed method is sensitive, efficient and reliable for fast determining complex chemicals, which is practical and possible for controlling quality of XFZYP. Related Articles | Metrics

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Highly Effectively Evaluating the quality consistency ofDihuang Pills by Quantified both HPLC and IR profilesthat assisted by antioxidant activity Xinxin Chen;Guoxiang Sun *;Jiayue Gao;Lei Wang;Yue Zou null    2015, 10 (2): 46-56.   Abstract （369）            Knowledge map    A high performance liquid chromatography (HPLC) method was developed for fingerprint profiling to evaluate the quality consistency of DHPs. Method validation results demonstrate that desired precision, repeatability, and a sample stability test was achieved. The HPLC fingerprints of samples were evaluated by PCA and the similarity analysis introduced by us. The infrared spectral fingerprint (IR-FP) was also achieved as a supplement of qualitative information. At last, DPPH assay was performed to assess the antioxidant activity of DHPs, in vitro, which was correlated to the fingerprint components. This study demonstrates that HPLC fingerprint combined with IR-FP and antioxidant ability provides a reliable and efficient methodology for the assessment of quality of the TCM and herbal preparations. Related Articles | Metrics

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Preventive effect of essential oil of Cinnamomum camphora leaves against mice allergic contact dermatitis Haizhu Xing, Qian Lu, Nianyun Yang Asina Journal Of Traditional Medicines

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A novel approach for quality control of Compound Danshen Tablets by using Multi-wavelength highperformance liquid chromatographic fingerprints and chemometrics to predict the antioxidant activity Jiao Chen, Guoxiang Sun, Yue Yu Asina Journal Of Traditional Medicines

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Integrated evaluation of HPLC fingerprints for the quality control of Ginseng Yang Rong Wan by multi-wavelength fusion fingerprint method Hanxiao Chi, Guoxiang Sun Asian Journal of Traditional Medicines    2019, 14 (4): 171-182.   Abstract （384）      PDF（pc） （1736KB）（1355）       Knowledge map    The aim of this study was to develop comprehensive evaluation methods for the quality control of Ginseng Yang Rong Wan (RSYRW). Multi-wavelength fusion fingerprints were successfully developed by high-performance liquid chromatography, which avoided the one-sidedness of single fingerprinting. Characteristic fingerprints of thirty batches of samples were generated at five wavelengths and evaluated by quantified ratio fingerprint method (QRFM). The results showed that thirty batches of samples were classified into seven grades. The methods established in this paper were found suitable for the analysis of Ginseng Yang Rong Wan. Related Articles | Metrics

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Research review in the main chemical constituents and pharmacological effects of Juglans mandshurica Maxim. Rui Guo, Zhuoyang Cheng, Xiao-xiao Huang, Shaojiang Song Asina Journal Of Traditional Medicines

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Anti-diabetic efficacy of young and mature leaf extract of Mangifera indica Abubakar Mohammed, Syed Ibrahim Rizvi Asina Journal Of Traditional Medicines

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Effect of Geographical location on yield and chemical composition of essential oils from three Eucalyptus species growing in Tanzania Ismail Almas, Ester Innocent, Francis Machumi, William Kisinza Asina Journal Of Traditional Medicines

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Research Progress on the Chemical Constituents and Biological Activities of Gelsemium elegans Chenxi Li, Lingzhi Li Asina Journal Of Traditional Medicines

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Antibacterial activity of four Combretum speciesused in Thai traditional medicine Wimaluk Nopsiri *;Yohji Ezure;Sunee Chansakaow;Somporn Putiyanan;Surapol Natakankitkul;Banyong Khantawa;Dammrong Santiarworn null    2015, 10 (1): 7-16.   Abstract （315）            Knowledge map    The medicinal uses of the leaves of four Combretum (Combretaceae) species which grow in northern Thailand, viz. Combretum deciduum Coll. & Hemsl., Combretum griffithii Heur. & M. A., Combretum latifolium Bl. and Combretum quadrangulare Kurz, were studied. The antibacterial activities of the crude extracts (obtained using n-hexane, dichloromethane, methanol and hot water) from the leaves of these four species were evaluated by the agar dilution method. All methanolic extracts showed potent antibacterial activity and unique antibacterial spectra. These were active against the Gram-positive bacterium, Staphylococcus aureus, and the Gram-negative bacterium, Pseudomonas aeruginosa but they were inactive against other Gram-negative bacteria, viz. Esherichia coli, Klebsiella pneumoniae, Enterobacter cloacae and Serratia marcescens. The degree of antibacterial activity of the methanolic extracts of the leaves of these four species was very similar, although the antibacterial activity of C. deciduum against S. aureus was slightly lower. These results support the ethnomedical use of these plants. The antibacterial activities of C. deciduum and C. latifolium are reported here for the first time. This is also the first report of the antibacterial activity of C. griffithii against a number of pathogenic bacteria. Related Articles | Metrics

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Review: diterpenoids from Croton genus (Euphorbiaceae) and their biological activity Shaochun Shi, Han Zhang, Shuangshuang Li, Qingbo Liu, Shaojiang Song Asina Journal Of Traditional Medicines

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Studies on the Chemical Components and Biological Activities of the genus of Caragana Tiantian Zhang, Yan Song, Di Zhou, Xuezheng Li, Ning Li Asina Journal Of Traditional Medicines

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Chemical constituents of the genus Pithecellobium: a systematic review Han Zhang, Zhiyang Yan, Xiaoxiao Huang* Asina Journal Of Traditional Medicines

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Antioxidant capacity of chemical constituents and antiinflammatory activity of ethanol extract from Semen sojae praeparatum Dan Yang, Yuhua liu, Yannian Wang, Jun Yin Asina Journal Of Traditional Medicines

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Research progress on flavonoids from the roots of Sophora flavescens Alt. and their biological activities Guoqing Long†, Jue Wang†, Dongyu Min, Yang Xu, Jingming Jia, Anhua Wang Asian Journal of Traditional Medicines    2021, 16 (6): 385-397.   Abstract （327）      PDF（pc） （1825KB）（716）       Knowledge map     Sophora flavescens Alt., a perennial herb of Sophora in Leguminosae family, was widely distributed in the north and south of China. Its root is utilized as a traditional Chinese medicine to clear heat, drain dampness, kill insect and promote urination by virtue of bitter and cold. Its chemical components are complex and diverse, mainly including alkaloids and flavonoids. Modern pharmacological studies have found that prenylflavonoids and quinolicidine alkaloids are the characteristic chemical constituents and the main active ingredients, with anti-inflammatory, anti-tumor, anti-oxidation, and other various biological activities. This study reviewed the chemical constituents of S. flavescens and the pharmacological effects of flavonoids in it in order to provide reference for further development. Related Articles | Metrics

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Antioxidant Activity of Pithecellobium clypearia (Jack) Benth dry branches and leaves Han Zhang, Yuxi Wang, Ming Bai, Xiaoxiao Huang Asina Journal Of Traditional Medicines

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Amide Alkaloids from the genus Piper: A Review of its Phytochemistry Weiyu Zhou, Ming Bai, Xiaoxiao Huang, Shaojiang Song Asina Journal Of Traditional Medicines

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Development and validation of HPTLC methodfor estimation of imperatorin in anti-obesity polyherbalformulation, Safoof-e-Muhazzil and some of its ingredients Kamran Javed Naquvi *;S. H. Ansari;Mohd. Ali;A. K. Najmi;Javed Ahamad null    2014, 9 (2): 34-44.   Abstract （503）            Knowledge map    Furanocoumarins are the coumarin derivatives distributed abundantly in higher plants. They can be grouped into the linear type and angular type. Imperatorin belongs to linear furanocoumarin class of compounds. It is reported to play a vital role in many biological activities. Therefore, a high-performance thin layer chromatography (HPTLC) densitometric method was developed and validated for the estimation of imperatorin. Imperatorin was separated on aluminium-backed silica gel 60 F254 plates using toluene:ethyl acetate (9:1, % v/v) as the mobile phase. This system was found to give a compact band of imperatorin at Rf value 0.49 ± 0.02. The limit of detection and limit of quantification were found to be 35.14 and 105.57 ng/spot, respectively. The proposed method was employed with a high degree of precision and accuracy for the estimation of imperatorin in Nardostachys jatamansi DC, Rosa damascena Mill., Apium graveolens Linn., Trachyspermum ammi Linn. and in-house Unani formulation Safoof-e-Muhazzil, containing these plants as ingredients. Related Articles | Metrics

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A review of phytochemistry and pharmacology perspectives of Clitoria ternatea L. Dingding Zhang, Zhuoyang Cheng, Xiaoxiao Huang Asian Journal of Traditional Medicines    2021, 16 (3): 153-160.   Abstract （544）      PDF（pc） （1019KB）（642）       Knowledge map    Clitoria ternatea L., belonging to the family Fabaceae and subfamily Papilonaceae, is an herbaceous perennial legume valued for its medicinal importance. Pharmacological investigations on this plant have shown it has a variety of medicinal properties, including antibacterial activities, antitumor activities, antioxidant activities, memory enhancing activities, wound healing activities, antipyretic activities and antiasthmatic activities. However, there are few studies on the chemical constituents of C. ternatea. The present research reviewed the chemical constituents and biological activities of C. ternatea to provide references for further research on this plant. Related Articles | Metrics

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Secondary metabolites from an endophytic fungus Aspergillus fumigatus from Solanum insanum L. M. Vindya Kanthi Munasinghe, N. Savitri Kumar, Nimal Adikaram, Lalith Jayasinghe, Hiroshi Araya, Yoshinori Fujimoto Asian Journal of Traditional Medicines    2021, 16 (2): 76-82.   Abstract （274）      PDF（pc） （906KB）（612）       Knowledge map    An endophytic fungus Aspergillus fumigatus, isolated from the fruits of Solanum insanum L., was cultured in potato dextrose broth medium. Chromatographic separation of the EtOAc extract led to the isolation of six secondary metabolites, identified as pseurotin A (1), fumigaclavine C (2), monomethylsulochrin (3), trypacidin (4), fumiquinazoline C (5) and guignasulfide (6) by spectral means. Compounds 2 and 3 showed brine shrimp toxicity with IC50 values of 147 and 74.2 μM, respectively, while compounds 4 and 5 showed slight inhibition on the growth of fungal pathogen Cladosporium cladosporioides. This is the first report of the isolation of guignasulfide (6) from A. fumigatus, which has been previously isolated only from an endophytic fungus Guignardia sp. Related Articles | Metrics

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Exploring the active ingredients, potential targets and pathways of quassinoids in Simaroubaceae plants by network pharmacology approachs Peng Zhao,Zhiyang Yan,Danqi Li,Xiaoxiao Huang Asina Journal Of Traditional Medicines

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Absolute configuration of curdione and its three isomers by NMR, ECD and DFT calculations: an insight into the scope of unsaturated ketone helicity rule based on an ECD study Feiting Zhang, Yuxin Li, Tianhui Zhu, Wenhe Zhang, Bin Qin, Song You Asina Journal Of Traditional Medicines

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Determination of the Total Content of Iodine in Wuhai Yingliu Pill and Neixiao Luoli Pill and Related Drugs within Them by UV-Vis spectroscopy Haiyan Huang;Xizhe Li;Zhong Yuan* null    2015, 10 (5): 105-109.   Abstract （263）            Knowledge map    A method for determination of total content of iodine in Wuhai Yingliu Pill and Neixiao Luoli Pill was developed by UV-Vis spectroscopy at 420 nm wavelength. Firstly, all the sample solutions in this work and the mixture of K2CO3-ZnSO4 and KClO3- NaCl were heated in dry bath at 300°C for about 3 h; Then the supernatant was collected after dissolving with water; At last, the absorbance was measured based on the catalytic of iodine in arsenic cerium oxide reduction reaction. Using this method, 23 samples were analyzed. A good linear regression relationship was obtained over the range of 0-1200 μg/L (r=0.9989) for standard solutions, the recovery rate was 96.54%, RSD=3.02% (n=9). The method was successfully applied to analyze these two Chinese patent medicines as a quantity control for clinical use in different types of thyroid disease. Related Articles | Metrics

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Shodhana (purificatory procedures) of Bhallataka (Semecarpusanacardium Linn.) fruit by traditional frying method Ilanchezhian Rangasamy *;Rabinarayan Acharya;Roshy J Chowallur;Vinay J Shukla null    2014, 9 (1): 1-7.   Abstract （447）            Knowledge map    Bhallataka (Semecarpus anacardium Linn.) is one among the wonderful drugs used to cure many diseases like inflammation, piles, cancer etc in Indian system of medicine. Shodhana (purificatory procedures) is must before administering the drug to the patients. The oily fraction in the pericarp of the fruit is responsible for the toxic nature of the drug. In southern parts of India, to purify Bhallataka fruit, frying method is followed traditionally. Here an attempt has been made to find out the impact of traditional folk-lore Shodhana (purificatory procedure) method by the physico-chemical parameters including HPTLC analysis. In 254 nm, raw bhallataka showed five spots but the shodhita Bhallataka showed only four spots, this difference may be due to the shodhana procedures. Related Articles | Metrics

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Research Progress on the chemical constituents and biological activities of Isatis indigotica Fort. Asina Journal Of Traditional Medicines

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Research review on the main chemical constituents and pharmacological effects of the samara derived from Ailanthus altissima (Mill.) Swingle Peng Zhao, Zhiyang Yan, Rui Guo, Xiaoxiao Huang Asina Journal Of Traditional Medicines

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Studies on the Chemical Components and Biological Activities of Stellera chamaejasme L. Qian Zhang, Yeqing Du, Zhuoyang Cheng, Xiaoxiao Huang, Shaojiang Song Asina Journal Of Traditional Medicines

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A network pharmacological study on the mechanism of Commiphora myrrha in the treatment of prostate cancer Jiaoyang Hou, Guodong Yao Asian Journal of Traditional Medicines    2021, 16 (6): 329-350.   Abstract （338）      PDF（pc） （8526KB）（411）       Knowledge map    Background: Prostate cancer (PCa) is one of the most common malignancies of the male genitourinary system. Commiphora myrrha (CM) has the potential to treat PCa, but the underlying mechanism is still unclear. Therefore, this study uses the network pharmacology method to investigate the target of CM in the treatment of PCa and related signal pathways, and further analyze the theoretical basis and potential mechanism of its treatment with PCa. Methods: All the components and targets of CM were retrieved from Traditional Chinese Medicine System Pharmacology Database and Analysis Platform (TCMSP). GeneCards andDisGeNET databases were used to collect PCa-related targets. String was used to build a target protein interaction network. The network of “active component-interaction target-related pathways” and protein-protein interaction network were constructed using Cytoscape, the functional enrichment analysis of GO and the enrichment analysis of KEGG pathway of CM in the treatment of PCa were performed using Metascape. Results: A total of 33 active ingredients including quercetin, β-sitosterol and ellagic acid were obtained, and 61 common targets of CM for PCa were obtained by screening intersection. The most frequent occurrences were AKT1, TP53, JUN, VEGFA, etc. These targets were mainly involved in biological processes, such as apoptotic signaling pathway, response to growth factor, and reactive oxygen species metabolic process, and were mainly concentrated in PI3K-Akt, MAPK and other signaling pathways. Conclusion: This study revealed the effective ingredients, potential targets and mechanism of action of CM in the treatment of PCa, aiming to provide a theoretical basis and reference for subsequent experimental studies. Related Articles | Metrics

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Studies on the chemical components and biological activities of the genus of Juncus Jiaxin Qi, Wanru Jiang, Gang Chen, Di Zhou, Ning Li Asian Journal of Traditional Medicines    2020, 15 (6): 375-393.   Abstract （459）      PDF（pc） （1513KB）（567）       Knowledge map    Juncus is the largest genus of Juncaceae family, with about 240 species around the world. There are 77 species, 1 variety and 10 deformations grown in China. Up to now, 117 components have been identified as phenanthrenes and dihydrophenanthrenes, which are the characteristic constituents of this genus, and 48 ones have been identified as triterpenoids, glycerides, coumarins, flavonoids from this genus. The reported constituents displayed diverse bioactivities, including antiproliferative, antimicrobial, anti-inflammatory, antioxidant, anxiolytic, sedative, spasmolytic, anticholinesterase and antialgal effects. This review summarized the research progress on the chemical components and pharmacological effects of the genus of Juncus so far. Related Articles | Metrics

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SARS-CoV-2: structure, host, virus source and pathogenesis Mingxue Li, Yueying Yang, Yang Liu, Mengzhu Zheng, Dejuan Sun, Hua Li, Lixia Chen Asian Journal of Traditional Medicines    2021, 16 (1): 32-52.   Abstract （470）      PDF（pc） （859KB）（469）       Knowledge map    Cancer is a serious threat to human life and a big problem in clinical treatment. Some natural active substances extracted from Traditional Chinese Medicine can effectively inhibit the growth of cancer cells, which is a new direction for finding more effective anticancer drugs. Osthole is a natural coumarin compound extracted from Traditional Chinese Medicines such as Cnidium monnieri, Angelica pubescens and Peucedanum praeruptorum Dunn. It has significant inhibitory activity against a variety of cancers. This paper summarizes the anticancer effects and molecular mechanisms of osthole in the treatment of cancers in recent years in order to provide references for further research. Related Articles | Metrics

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Research progress on the main chemical constituents and pharmacological effects of Piper betle L. Zhiyong Xu, Yufei Xi, Xiaoxiao Huang, Shaojiang Song Asian Journal of Traditional Medicines    2021, 16 (5): 294-308.   Abstract （338）      PDF（pc） （2159KB）（469）       Knowledge map    The Piper betle, belonging to Piper genus of the Piperaceae family, is an evergreen and perennial creeper used in several traditional medicines. This plant has been known to possess antioxidant, antitumor, antibacterial, anti-inflammatory and antimalarial activities. A wide range of chemical compounds including alkaloids, simple phenylpropanoids, lignans, flavonoids, steroids, triterpenoids, sesquiterpenes, monoterpenes have been isolated from this plant. The present review summarized the information concerning phytochemistry and biological activity of P. betle, providing references for the future research of this plant. Related Articles | Metrics

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A preparation technology to obtain 5β-hydroxyacovenosigenin from roots of Streptocaulon juventas using ethanol refluxing and hydrochloric acid hydrolysis method Chengcheng Cai, Hua Wang, Shuai Yuan, Na Han, Zhihui Liu, Jun Yin Asina Journal Of Traditional Medicines

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The detailed anti-tumor mechanisms of daphnanetype diterpenoids from Genkwa flos Jingjie Chen, Xinyue Shang, Fengying Han, Yan Zhang, Guodong Yao, Shaojiang Song Asina Journal Of Traditional Medicines

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Study on the quality control of Shang-Ke Bone-Knitting Tablet (SKBT) Zehai Song;Luhui Li;Qiao Li;Na Han;Zhihui Liu;Jun Yin * null    2015, 10 (3): 69-78.   Abstract （273）            Knowledge map    Shang-ke Bone-knitting tablet (SKBT) is widely used in China because of its excellent efficiency on bone-fracture healing, which is composed of 12 kinds of drugs. In order to improve and strengthen the quality control standards of SKBT, three drugs, Asterias Amurensis (hai xing), Olibanum (zhi ru xiang), Myrrha (zhi mo yao), were chosen because of their contributions to the efficacy of SKBT and were identified by thin-layer chromatography (TLC). The results showed that the TLC method we have developed was reliable, accurate, simple and easily operated. The method was appropriate to control the quality of SKBT. Except for the TLC part, a simple, rapid and sensitive high-performance liquid chromatography (HPLC)-UV method has been developed to simultaneously quantify three active saponins of Notoginseng Radix et Rhizoma (notoginsenoside R1, ginsenoside Rg1 and ginsenoside Rb1). Methodological investigation indicated that the developed HPLC assay could be readily utilized as a quality control and quantitative analysis method of SKBT. Related Articles | Metrics

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Research progress on polysaccharide compositions of Dendrobium officinale Lili Wang, Liu Bai Asian Journal of Traditional Medicines    2022, 17 (2): 72-83.   Abstract （294）      PDF（pc） （1808KB）（556）       Knowledge map    More and more attention has been paid to the polysaccharide components of Dendrobium officinale (D. officinale). They are rich in active components and have extensive pharmacological effects. This paper systematically summarized the extraction, separation, purification process, content determination, chemical compositions and pharmacological activities of D. officinale polysaccharides, which provided the basis for the preparation, quality control and further development and utilization of the medicinal materials. Related Articles | Metrics

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Progress on chemical constituents and pharmacological effects of Piper nigrum L. Ye Chang, Yuxi Wang, Xiaoxiao Huang, Shaojiang Song Asian Journal of Traditional Medicines    2022, 17 (5): 212-225.   Abstract （178）      PDF（pc） （1494KB）（249）       Knowledge map    Piper nigrum L., belonging to Piper genus of the Piperaceae family, is a medicinal and edible plant. Studies have shown that there are many chemical constituents in this plant, including alkaloids, lignans, steroids and other compounds. In addition, some chemical components of P. nigrum have potential values to treat cancer, inflammation and other diseases. Research progress on the chemical constituents and pharmacological effects of P. nigrum was reviewed in this study to better explore its potential medicinal value. Related Articles | Metrics